Metabolic factors and the risk of small intestine cancers: Pooled study of 800 000 individuals in the metabolic syndrome and cancer project

To explore the largely unknown etiology of small intestine cancer, we examined metabolic factors and risk cancer overall by subtypes. Among 404 220 women 403 265 men in six European cohorts, applied Cox regression with adjustment for smoking body mass index (BMI), to calculate sex-specific hazard ratios (HRs) levels BMI, mean arterial pressure (MAP) plasma total cholesterol, triglycerides glucose. We also calculated HRs these combined (metabolic score; MetS) used Wald test statistics investigate pairwise interactions between on risk. performed analyses separately per subtype (neuroendocrine tumors [NETs] adenocarcinomas). During a median follow-up 16.9 years, 144 195 were diagnosed including 184 NETs 99 adenocarcinomas. men, no main associations or observed relation cancer. women, positively linearly associated (HR standard deviation [SD]: 1.23, 95% confidence interval [CI]: 1.04-1.46), positive association was MetS SD: 1.25, CI: 1.02-1.52). Positive among cholesterol (P = .0005), MAP glucose .009), Glucose adenocarcinomas women. This large, prospective study suggests that elevated triglycerides, interaction, confer an increased but not men.